Zinc α2-Glycoprotein: A Multidisciplinary Protein
نویسندگان
چکیده
منابع مشابه
Zinc A2-Glycoprotein: A Multidisciplinary Protein
Zinc A2-glycoprotein (ZAG) is a protein of interest because of its ability to play many important functions in the human body, including fertilization and lipid mobilization. After the discovery of this molecule, during the last 5 decades, various studies have been documented on its structure and functions, but still, it is considered as a protein with an unknown function. Its expression is reg...
متن کاملZinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites.
Zinc α2 glycoprotein (ZAG) is an adipokine with a class I MHC protein fold and is associated with obesity and diabetes. Although its intrinsic ligand remains unknown, ZAG binds the dansylated C11 fatty acid 11-(dansylamino)undecanoic acid (DAUDA) in the groove between the α1 and α2 domains. The surface of ZAG has approximately 15 weak zinc-binding sites deemed responsible for precipitation from...
متن کاملZinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice
Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum and ZAG mRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated the effects of ZAG administration on the body weight, body fat and glucose met...
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Zinc-α2-glycoprotein (ZAG) is an adipokine with the potential as a therapeutic agent in the treatment of obesity and type 2 diabetes. In this study we show that human ZAG, which is a 41-kDa protein, when administered to ob/ob mice at 50 μg/d(-1) orally in the drinking water produced a progressive loss of body weight (5 g after 8 d treatment), together with a 0.5 C increase in rectal temperature...
متن کاملSerum Levels of the Adipokine Zinc-α2-glycoprotein Are Decreased in Patients with Hypertension
Objective. Zinc-α2-glycoprotein (ZAG) has recently been proposed as a new adipokine involved in body weight regulation. The purpose of this study is to investigate serum levels of ZAG in patients with hypertension and its association with related characteristics. Methods. 32 hypertension patients and 42 normal controls were recruited and the relationship between serum ZAG, total and high molecu...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2008
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-07-2195